Ariceum Therapeutics and Nusano Announce Multi-Isotope Supply Agreement

  • Agreement includes Actinium-225 (Ac-225) and Lutetium-177 (Lu-177) to support Ariceum’s therapeutic programs

BERLIN, Germany and WEST VALLEY CITY, Utah – Oct. 14, 2025 – Ariceum Therapeutics (Ariceum), a targeted radiotherapeutics company dedicated to setting new standards in cancer care, and Nusano, a physics company transforming the production of radioisotopes, today announced the signing of a multi-isotope supply agreement to support Ariceum’s novel radiotherapeutic pipeline.

The agreement gives Ariceum access to Nusano-produced radioisotopes, including actinium-225 (Ac-225) and lutetium-177 (Lu-177).

“Radiotherapeutics have the potential to redefine the standard of care in oncology,” said Manuel Sturzbecher-Höhne, Chief Technology Officer of Ariceum Therapeutics. “This agreement further strengthens our ability to advance 225Ac-SSO110, which is currently being investigated in a Phase 1/2 trial in patients with extensive-stage small cell lung cancer and Merkel cell carcinoma. Reliable access to actinium-225 ensures we can deliver on our commitment to developing transformative therapies for patients facing these aggressive and underserved cancers.”

The Nusano radioisotope production platform combines time-proven technology from universities and world-class research centers with the company’s patented particle acceleration technology. The result is the first significant advancement in radioisotope production in decades – a platform that’s smaller and more efficient than existing methods, and capable of the simultaneous manufacturing of up to 12 different radioisotopes.

“Nusano’s production capabilities are designed to stabilize supply chains and enable innovation,” said Chris Lowe, CEO of Nusano. “Our scalable production allows us to work with drug developers from the earliest stages through commercial drug availability. We look forward to working with Ariceum on their current and future therapeutic candidates.”

 

About Ariceum Therapeutics

Ariceum Therapeutics is a clinical-stage oncology company dedicated to redefining the future of care through targeted radiotherapeutics for patients with aggressive and hard-to-treat cancers. The company’s lead program, 225Ac-SSO110, a novel antagonist of the somatostatin type 2 receptor (SSTR2) with best-in-class potential, is currently being investigated in the Phase 1/2 SANTANA-225 study as the first maintenance radiotherapy for extensive stage small cell lung cancer (ES-SCLC) and Merkel Cell Carcinoma (MCC) –two diseases with limited options and poor prognosis. Ariceum is also developing a clinical product candidate ATT001, a novel radiolabeled I-123 PARP inhibitor designed to deliver subcellular precision radiotherapy to aggressive solid tumors.

Headquartered in Berlin, Ariceum operates across Germany, Switzerland, Australia, the United Kingdom, and the United States. The company is supported by leading global life sciences investors, including EQT Life Sciences, HealthCap, Pureos Bioventures, Andera Partners, and Earlybird Venture Capital.

About Nusano

Nusano is a privately held physics company working to stabilize supply chains, advance American national security by reducing dependency on foreign supply, and enable once-in-a-generation innovations in fields ranging from healthcare to nuclear energy. The company is commercializing platform technologies for radioisotope production, stable isotope enrichment, and advanced separation techniques. Together, these proprietary systems and methods are poised to supply the fight against cancer, fuel the nuclear renaissance, and deliver critical minerals for the modern world. For more, visit nusano.com.

Contacts:

Ariceum Therapeutics
Investors
Kevin Lui
Director, Investor Relations
kevin.lui@precisionaq.com

Media
Genevieve Britton
Group Account Director, Public Relations
genevieve.britton@precisionaq.com

 

Nusano
Investors
Joyce Allaire
LifeSci Advisors, LLC, 212-915-2569
jallaire@lifesciadvisors.com

Media
Scott Larrivee
Nusano, 608-345-6629
scott.larrivee@nusano.com

Ariceum Therapeutics Data at the 2025 European Association of Nuclear Medicine Annual Congress Further Supports the Advancement of 225Ac-SSO110 for Extensive Stage Small Cell Lung Cancer and Merkel Cell Carcinoma

  • Oral presentation by Dr Zan highlighted novel Phase 1/2 SANTANA-225 study design of 225Ac-SSO110 in patients with ES-SCLC or MCC
  • 225Ac-SSO110 achieves superior pharmacokinetics with minimal re-distribution of Actinium-225 daughter isotopes and 100% survival in preclinical studies
  • Initial safety data from SANTANA-225 expected in 2026

Berlin, Germany, 9 October 2025 – Ariceum Therapeutics (Ariceum), a targeted radiotherapeutics company dedicated to setting new standards in cancer care, today highlighted two oral presentations showcasing the SANTANA-225 Phase 1/2 clinical trial design and preclinical data supporting 225Ac-SSO110’s differentiated profile as a targeted alpha radioligand therapy for somatostatin receptor 2 (SSTR2) positive malignancies at the 38th Annual Congress of the European Association of Nuclear Medicine (EANM25), held from October 4 – 8, 2025 in Barcelona, Spain.

“These oral presentations demonstrate Ariceum’s commitment to leading innovation in targeted radiotherapeutics,” said Germo Gericke, MD, Chief Medical Officer of Ariceum Therapeutics. “For the first time, we are presenting data showing minimal in-vivo redistribution of daughter radionuclides with 225Ac-SSO110, a non-internalizing SSTR2 antagonist, an important advance in our understanding of targeted alpha therapy. In parallel, our SANTANA-225 study showcases an innovative, first‑in-class approach for patients with ES‑SCLC and MCC. With the SANTANA-225 initial safety readout expected in 2026 and preliminary efficacy in 2027, we remain committed to setting new standards in both research and patient care for diseases with high unmet needs.”

Details of the Presentations:

Title: SANTANA-225: A multicentre, open-label, Phase I/II study investigating the safety, tolerability, and preliminary efficacy of 225Ac-SSO110 in participants with extensive stage small cell lung cancer (ES-SCLC) or Merkel cell carcinoma (MCC) receiving Standard of Care (SoC); Presentation # OP-780

This presentation, presented by Dr. Elcin Zan, Cleveland Clinic, highlighted the design of Ariceum’s SANTANA-225 Phase 1/2 clinical trial (NCT06939036) evaluating 225Ac-SSO110 for the treatment of first line (1L) maintenance ES-SCLC or 1L MCC. This global, open-label study will assess the safety, tolerability, preliminary efficacy, and recommended Phase 2 dose of 225Ac-SSO110 in patients receiving immune checkpoint inhibitor (CPI) therapy. The clinical trial is expected to enroll approximately 20 patients in the dose escalation phase of the study followed by additional optional expansion cohorts of 15 patients per indication. 225Ac-SSO110 is the first SSTR2-targeting antagonist labelled with Actinium-225 to undergo human trials in combination with CPI therapy.

Title: Improved Tumour Targeting and Efficacy with Comparable Daughter Redistribution of 225Ac-SSO110 versus 225Ac-DOTA-TATE in a Preclinical SCLC Model; Presentation # OP-658

A second oral presentation at EANM25 showcased the superior pharmacokinetic profile of 225Ac-SSO110 versus 225Ac-DOTA-TATE, demonstrating comparable biodistribution to the internalizing agonist, alongside enhanced tumor uptake and a favorable therapeutic index.

The Company evaluated the biodistribution of Actinium-225 (Ac-225) and its daughter radionuclides, including Bismuth-213 (Bi-213), after injection of Actinium-225-labeled SSO110, a non-internalizing SSTR2 antagonist, or the internalizing SSTR2 agonist DOTA-TATE in an ES-SCLC xenograft model. Bismuth-213 plays a critical role in therapeutic assessment as the longest half-life alpha-emitting daughter of Actinium-225. Its localization and retention within target tissue are key determinants of both safety and efficacy in targeted alpha therapies.

The study results demonstrate that 225Ac-SSO110’s differentiated binding profile enables superior tumor uptake and retention, compared with 225Ac-DOTA-TATE. Importantly, 225Ac-SSO110 exhibited similar retention of daughter radionuclides as the internalizing agonist 225Ac-DOTA-TATE and a more favorable therapeutic index. The short blood circulation half-life of 225Ac-SSO110 helps limit systemic redistribution of daughter radionuclides, reducing the potential off-target exposure. Both treatments were well-tolerated with no histopathological abnormalities observed. In prior studies 225Ac-SSO110 has achieved complete tumor remissions after a single injection of 30 kBq, whereas 225Ac-DOTA-TATE failed to control tumor growth with the same injected activity.

These results reinforce the therapeutic potential of 225Ac-SSO110 as a next-generation alpha-emitting radioligand therapy for SSTR2-positive tumors, such as ES-SCLC and MCC.

Abstracts are available in the EANM25 Abstracts Book and the complete presentations can be accessed on the EANM 2025 congress website.

 

About Ariceum Therapeutics

Ariceum Therapeutics is a clinical-stage oncology company dedicated to redefining the future of care through targeted radiotherapeutics for patients with aggressive and hard-to-treat cancers. The company’s lead program, 225Ac-SSO110, a novel antagonist of the somatostatin type 2 receptor (SSTR2) with best-in-class potential, is currently being investigated in the Phase 1/2 SANTANA-225 study as the first maintenance radiotherapy for extensive stage small cell lung cancer (ES-SCLC) and Merkel Cell Carcinoma (MCC) – two diseases with limited options and poor prognosis. Ariceum is also developing ATT001, a novel radiolabeled I-123 PARP inhibitor designed to deliver subcellular precision radiotherapy to aggressive solid tumors.

Headquartered in Berlin, Ariceum operates across Germany, Switzerland, Australia, the United Kingdom, and the United States. The company is supported by leading global life sciences investors, including EQT Life Sciences, HealthCap, Pureos Bioventures, Andera Partners, and Earlybird Venture Capital.

For further information, please contact:

Investors
Kevin Lui
Director, Investor Relations
kevin.lui@precisionaq.com

Media
Genevieve Britton
Group Account Director, Public Relations
genevieve.britton@precisionaq.com

Ariceum Therapeutics Appoints David Schilansky as Chief Executive Officer and Announces New Leadership to Advance Next Phase of Development

  • David Schilansky transitions to CEO, bringing 25 years of company-building, scaling and financing to advance Ariceum’s pipeline of novel radiotherapeutics
  • Initiation of Phase 1/2 SANTANA-225 study of 225Ac-SSO110 Extensive stage small cell lung cancer (ES-SCLC) and Merkle cell carcinoma (MCC) by 2H 2025; initial data expected in 2026

Berlin, Germany, 26 August 2025 – Ariceum Therapeutics (Ariceum), a targeted radiotherapeutics company dedicated to setting new standards in cancer care, today announced that David Schilansky, previously Ariceum’s Chief Financial Officer, has been appointed as the Company’s new Chief Executive Officer. Mr. Schilansky succeeds Co-Founder and former CEO Manfred Rüdiger, PhD, who will continue to serve as a strategic advisor to the Company.

“I look forward to leading Ariceum’s next chapter of growth, and I am grateful to the Board for entrusting me with this mission. I want to thank Manfred for onboarding me in the company, passing the CEO helm, and for building Ariceum into the pioneering company it is today,” said David Schilansky, Chief Executive Officer of Ariceum Therapeutics. “Standing at the forefront of radiopharmaceutical innovation, Ariceum is uniquely positioned to redefine the treatment paradigms for ES-SCLC and MCC with our lead candidate, 225Ac-SSO110, which has the potential to be both first- and best-in-class. We expect to report initial safety data in early 2026 and preliminary efficacy findings in 2027, milestones that mark a pivotal transformation for our company. As we embark on this new chapter, we remain focused on our mission to advance radioligand science and drive meaningful improvements in patient outcomes. Leveraging our team’s deep expertise in the RLT field and strong track record in scaling biotech companies, we are well-positioned to maximize 225Ac-SSO110’s potential and to establish Ariceum as a global radiopharmaceutical leader.”

The Company also announced leadership transitions and a new executive team to support Ariceum’s next phase of development:

  • Germo Gericke, an accomplished radiopharmaceutical leader, will continue serving as Ariceum’s Chief Medical Officer
  • Susanna Mesa, a global operations and strategy biotech executive, has been appointed as Chief Operating Officer
  • Manuel Sturzbecher-Höhne, PhD, formerly Head of CMC and Radiopharm Development, has been promoted to Chief Technology Officer
  • Greg Mullen, PhD, formerly Chief Operations Officer of Ariceum, and Serge Sagodira, PhD, formerly Chief Business Officer of Ariceum, will be leaving the Company to pursue other opportunities

“Together, these accomplished leaders bring the vision, operational excellence, financial stewardship, and an innovative mindset to propel Ariceum’s continued evolution. David’s leadership and strategic acumen will be pivotal in steering Ariceum through its next phase of growth,” said Eduardo Bravo, Chairman of Ariceum Therapeutics. “We would also like to extend our sincere appreciation to Manfred, who is stepping down for personal reasons as part of a planned transition, for his leadership, dedication and strategic contributions, which have been instrumental in shaping Ariceum’s vision to date. We would also like to extend our appreciation for Dr. Greg Mullen and Dr. Serge Sagodira’s invaluable contributions and unwavering commitment to the company’s mission. We wish them the very best as they embark on their next chapters.”

 

About Ariceum Therapeutics

Ariceum Therapeutics is a clinical-stage oncology company dedicated to redefining the future of care through targeted radiotherapeutics for patients with aggressive and hard-to-treat cancers. The company’s lead program, 225Ac-SSO110, a novel antagonist of the somatostatin type 2 receptor (SSTR2) with best-in-class potential, is currently being investigated in the Phase 1/2 SANTANA-225 study as the first maintenance radiotherapy for extensive stage small cell lung cancer (ES-SCLC) and Merkel Cell Carcinoma (MCC) –two diseases with limited options and poor prognosis. Ariceum is also developing a clinical product candidate ATT001, a novel radiolabeled I-123 PARP inhibitor designed to deliver subcellular precision radiotherapy to aggressive solid tumors.

Headquartered in Berlin, Ariceum operates across Germany, Switzerland, Australia, the United Kingdom, and the United States. The company is supported by leading global life sciences investors, including EQT Life Sciences, HealthCap, Pureos Bioventures, Andera Partners, and Earlybird Venture Capital.

For further information, please contact:

Investors
Kevin Lui
Director, Investor Relations
kevin.lui@precisionaq.com

Media
Genevieve Britton
Group Account Director, Public Relations
genevieve.britton@precisionaq.com

U.S. FDA Grants Orphan Drug Designation to Ariceum Therapeutics’ Proprietary Radiopharmaceutical Cancer Therapy

  • 225Ac-satoreotide is a first-in-class Actinium-labelled somatostatin receptor 2 antagonist targeting extensive-stage Small Cell Lung Cancer or Merkel Cell Carcinoma
  • Orphan Drug Designation follows outstanding preclinical data and FDA IND clearance
  • Phase I/II human trials set to commence in Q1 2025 as a ‘theranostic’ targeted radionuclide treatment

Berlin, Germany, 6 February 2025 – Ariceum Therapeutics (Ariceum), a private biotech company developing radiopharmaceutical products for the diagnosis and treatment of certain hard-to-treat cancers, today announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation (ODD) to 225Ac-SSO110 (satoreotide) for the treatment of patients with Small Cell Lung Cancer (SCLC).

SCLC is a deadly condition that represents a significant unmet medical need due to the limited number of treatment options available to patients with this aggressive form of cancer. Two-thirds of SCLC patients are diagnosed at an advanced stage where the disease has already spread significantly, resulting in a poor prognosis and a 5-10% overall five-year survival rate. Ariceum will commence Phase I/II human clinical development of 225Ac-satoreotide under the trial name, SANTANA-225 in Q1 2025.

Manfred Rüdiger, Chief Executive Officer at Ariceum Therapeutics, said: “Receiving ODD for 225Ac-satoreotide is a recognition of its potential as a treatment option for patients with SCLC and an important regulatory milestone for Ariceum. The FDA’s ODD will support our objective to accelerate the development of 225Ac-satoreotide through human trials to provide a potentially life-saving therapy to patients with limited alternatives.”

The FDA provides ODD to drugs and biologics that demonstrate potential for the diagnosis and/or treatment of rare diseases or conditions that affect fewer than 200,000 people in the U.S. The designation provides development and commercial incentives for designated compounds and medicines, including eligibility for seven years of market exclusivity in the U.S. after product approval, FDA assistance in clinical trial design, and an exemption from FDA user fees.

In October 2024, Ariceum published outstanding preclinical data demonstrating the significant potential of 225Ac-satoreotide to outperform SSTR2 targeting agonists. 225Ac-satoreotide showed a high frequency of complete durable responses and 100% survival supporting advanced clinical development in SCLC, MCC, and other aggressive cancers. 225Ac-satoreotide in combination with its companion patient selection tracer 68Ga-SSO120 is being developed as a ‘theranostic pair’ for the combined diagnosis and targeted radionuclide treatment of multiple indications expressing SSTR2, such as SCLC, MCC, and other aggressive, hard-to-treat cancers.

-Ends-

About Ariceum Therapeutics
Ariceum Therapeutics is a private, clinical stage radiopharmaceutical company focused on the diagnosis and precision treatment of certain neuroendocrine and other aggressive, hard-to-treat cancers. The name Ariceum is an anagram of ‘Marie Curie’ whose discovery of radium and polonium have been huge contributions to finding treatments for cancer.

Ariceum’s lead targeted systemic radiopharmaceutical candidate, SSO110 (“satoreotide”) labelled with Lutetium-177 (177Lu) and Actinium-255 (225Ac) is an antagonist of the somatostatin type 2 (SSTR2) receptor which is overexpressed in aggressive neuroendocrine tumours (NETs) such as small cell lung cancer (SCLC) or Merkel Cell Carcinoma (MCC), all of which have limited treatment options and poor prognosis. Satoreotide is being developed as a ‘theranostic pair’ for the combined diagnosis and targeted radionuclide treatment of these tumours. Ariceum is also developing a radiolabelled PARP-inhibitor (ATT001), currently in Phase 1 clinical development under the trial name CITADEL-123. ATT001 was part of the acquisition of Theragnostics Ltd which was closed in June 2023.

Ariceum Therapeutics, launched in 2021, acquired all rights to satoreotide from Ipsen, which has remained a shareholder of the Company. Ariceum is headquartered in Berlin, with operations in Germany, Switzerland, Australia, the United Kingdom, and the United States.

Ariceum is led by a highly experienced management team and supported by specialist investors including EQT Life Sciences (formerly LSP), HealthCap, Pureos Bioventures, Andera Partners, and Earlybird Venture Capital. For further information, please visit www.ariceum-therapeutics.com.

For further information, please contact:

Ariceum Therapeutics
Manfred Rüdiger, CEO
Email: info@ariceum-therapeutics.com

Optimum Strategic Communications
Zoe Bolt, Charlotte Hepburne-Scott, Elena Bates
Tel: +44 (0) 20 3882 9621
Email: ariceum@optimumcomms.com

 

FDA Clears Ariceum Therapeutics’ 225Ac-Satoreotide Phase I/II Clinical Study in Patients with Small Cell Lung Cancer or Merkel Cell Carcinoma

  • 225Ac-SSO110 (satoreotide) is a first in class Actinium-labelled SSTR2 receptor antagonist
  • Phase I/II SANTANA-225 study on track to enrol patients in Q1 2025

Berlin, Germany, 14 January 2025 – Ariceum Therapeutics (Ariceum), a private biotech company developing radiopharmaceutical products for the diagnosis and treatment of certain hard-to-treat cancers, today announced that the US Food and Drug Administration (FDA) has cleared its investigational new drug (IND) application to commence a Phase I/II clinical trial (‘SANTANA-225’) of its proprietary radiolabelled peptide, 225Ac-SSO110, in patients with small cell lung cancer (SCLC) or Merkel Cell Carcinoma (MCC).

The SANTANA-225 trial is a global, open-label Phase I/II study, that will assess the safety, tolerability, preliminary efficacy and recommended Phase II dose of 225Ac-SSO110 in patients with extensive-stage SCLC or MCC who are on first-line maintenance therapy with checkpoint inhibitors. Ariceum is working with its partners and clinical sites in the US and other countries to commence recruitment of patients in Q1 2025.

Germo Gericke, Chief Medical Officer at Ariceum Therapeutics, said: “This is an important milestone, not only for Ariceum but for the whole field of targeted radionuclide cancer treatments. 225Ac-SSO110 is the first somatostatin receptor 2 (SSTR2) antagonist labelled with Actinium-225 to undergo human trials, providing the optimum combination of a long half-life α particle emitter with a long tumour retention tracer. Based on encouraging clinical data with 177Lu-SSO110 and very promising pre-clinical data of 225Ac-SSO110, we are very optimistic about the potential for patients with difficult to treat cancers.”

225Ac-SSO110 is being developed together with its companion patient selection tracer 68Ga-SSO120 as a ‘theranostic pair’ targeted radionuclide treatment of multiple indications expressing SSTR2, such as SCLC, MCC, and other aggressive cancers. Ariceum has recently expanded its global supply agreements for the medical radionuclides Actinium-225 (225Ac) and Lutetium-177 (177Lu), which will be used to radiolabel SSO110.

-Ends-

About Ariceum Therapeutics
Ariceum Therapeutics is a private, clinical stage radiopharmaceutical company focused on the diagnosis and precision treatment of certain neuroendocrine and other aggressive, hard-to-treat cancers. The name Ariceum is an anagram of ‘Marie Curie’ whose discovery of radium and polonium have been huge contributions to finding treatments for cancer.

Ariceum’s lead targeted systemic radiopharmaceutical candidate, SSO110 (“satoreotide”) labelled with Lutetium-177 (177Lu) and Actinium-255 (255Ac) is an antagonist of the somatostatin type 2 (SSTR2) receptor which is overexpressed in aggressive neuroendocrine tumours (NETs) such as small cell lung cancer (SCLC) or Merkel Cell Carcinoma (MCC), all of which have limited treatment options and poor prognosis. Satoreotide is being developed as a ‘theranostic pair’ for the combined diagnosis and targeted radionuclide treatment of these tumours. Ariceum is also developing a radiolabelled PARP-inhibitor (ATT001), currently in Phase 1 clinical development under the trial name CITADEL-123. ATT001 was part of the acquisition of Theragnostics Ltd which was closed in June 2023.

Ariceum Therapeutics, launched in 2021, acquired all rights to satoreotide from Ipsen, which has remained a shareholder of the Company. Ariceum is headquartered in Berlin, with operations in Germany, Switzerland, Australia, the United Kingdom, and the United States.

Ariceum is led by a highly experienced management team and supported by specialist investors including EQT Life Sciences (formerly LSP), HealthCap, Pureos Bioventures, Andera Partners, and Earlybird Venture Capital. For further information, please visit www.ariceum-therapeutics.com.

For further information, please contact:

Ariceum Therapeutics
Manfred Rüdiger, CEO
Email: info@ariceum-therapeutics.com

Optimum Strategic Communications
Zoe Bolt, Charlotte Hepburne-Scott, Elena Bates
Tel: +44 (0) 20 3882 9621
Email: ariceum@optimumcomms.com

 

Ariceum Therapeutics and ITM Enter Supply Agreement for Therapeutic Medical Radioisotope Actinium-225

Berlin, Germany / Garching / Munich, January 13, 2025 – Ariceum Therapeutics (Ariceum), a private biotech company developing radiopharmaceutical products for the diagnosis and treatment of certain hard-to-treat cancers, and ITM Isotope Technologies Munich SE (ITM), a leading radiopharmaceutical biotech company, today announced the execution of a supply agreement for non-carrier-added (n.c.a.) Actinium-225 (Ac-225) to support the development of Ariceum’s novel targeted radiopharmaceutical therapies (RPT) pipeline, including lead radiopharmaceutical drug, satoreotide for the treatment of aggressive, difficult-to-treat cancers.

Under the terms of the agreement, ITM will supply the therapeutic medical radioisotope, Ac-225, produced by Actineer™ Inc, ITM’s joint venture company with Canadian Nuclear Laboratories, for use in Ariceum’s Actinium-based pipeline candidates. Actineer is advancing cutting-edge technologies to secure and expand its supply chain and produce industrial-scale quantities of Ac-225 at rapid speed by irradiating Radium-226 (Ra-226) in cyclotrons to meet the growing demand for this promising medical radioisotope on a global scale. Additional details of the supply agreement have not been disclosed.

“Securing a reliable and plentiful supply of n.c.a. Ac-225 is critical to our efforts in developing innovative cancer treatments with our pipeline of novel targeted radiopharmaceuticals,” commented Manfred Rüdiger, Chief Executive Officer at Ariceum Therapeutics. “Our agreement with ITM and its joint venture company Actineer supports our access to valuable resources needed to explore the full potential of Ac-225 in unlocking and advancing new Targeted Alpha Therapy approaches for patients living with difficult-to-treat cancers.”

Ac-225 is a rare medical radioisotope used in RPTs for the treatment of various cancer indications. It emits high-energy alpha particles with a short penetration range in tissue, enabling precise targeting of tumor cells. This unique quality has made Ac-225 an increasingly sought-after resource in the field, with growing demand. Its natural scarcity and manufacturing complexities have contributed to critical shortages that have threatened the development of novel radiopharmaceuticals that have the potential to treat challenging cancer indications.

“We value our partnership with Ariceum which marks a significant step forward in advancing our mission to provide this critical medical radioisotope to the radiopharmaceutical industry,” said Dr. Andrew Cavey, Chief Executive Officer at ITM. “With our extensive experience in the production and supply of Lutetium-177, we are well-equipped to apply that expertise to Actinium-225 via our joint venture, Actineer. Our agreement with Ariceum strengthens our commitment to advancing innovative solutions for cancer treatment and to meeting the needs of our partners and people living with cancer worldwide.”

-Ends-

About Ariceum Therapeutics
Ariceum Therapeutics is a private, clinical stage radiopharmaceutical company focused on the diagnosis and precision treatment of certain neuroendocrine and other aggressive, hard-to-treat cancers. The name Ariceum is an anagram of ‘Marie Curie’ whose discovery of radium and polonium have been huge contributions to finding treatments for cancer.

Ariceum’s lead targeted systemic radiopharmaceutical candidate, 177Lu-satoreotide tetraxetan (“satoreotide”), is an antagonist of the somatostatin type 2 (SSTR2) receptor which is overexpressed in aggressive neuroendocrine tumours (NETs) such as small cell lung cancer (SCLC) or Merkel Cell Carcinoma (MCC), all of which have limited treatment options and poor prognosis. Satoreotide is being developed as a ‘theranostic pair’ for the combined diagnosis and targeted radionuclide treatment of these tumours. Ariceum is also developing a radiolabelled PARP-inhibitor (ATT001), currently in Phase 1 clinical development under the trial name CITADEL-123. ATT001 was part of the acquisition of Theragnostics Ltd which was closed in June 2023.

Ariceum Therapeutics, launched in 2021, acquired all rights to satoreotide from Ipsen, which has remained a shareholder of the Company. Ariceum is headquartered in Berlin, with operations in Germany, Switzerland, Australia, the United Kingdom, and the United States.

Ariceum is led by a highly experienced management team and supported by specialist investors including EQT Life Sciences (formerly LSP), HealthCap, Pureos Bioventures, Andera Partners, and Earlybird Venture Capital. For further information, please visit www.ariceum-therapeutics.com.

About ITM Isotope Technologies Munich SE
ITM, a leading radiopharmaceutical biotech company, is dedicated to providing a new generation of radiomolecular precision therapeutics and diagnostics for hard-to-treat tumors. We aim to meet the needs of cancer patients, clinicians and our partners through excellence in development, production and global supply. With improved patient benefit as the driving principle for all we do, ITM advances a broad precision oncology pipeline, including multiple phase III studies, combining the company’s high-quality radioisotopes with a range of targeting molecules. By leveraging our two decades of pioneering radiopharma expertise, central industry position, and established global network, ITM strives to provide patients with more effective targeted treatment to improve clinical outcome and quality of life. www.itm-radiopharma.com

About Actineer, Inc.
Actineer™ Inc. is a joint venture company between Canadian Nuclear Laboratories (CNL) and ITM Isotope Technologies Munich SE (ITM) dedicated to advancing Ac-225 technologies, quickly securing supply, and producing industrial-scale quantities of this valuable, rare medical radioisotope for the treatment of cancer. Founded in October 2023, Actineer™ Inc. together with its strong supply chain collaborators seeks to progress Ac-225 development, production, and processing technologies. It has established short-term production capabilities that is expected to lead to significantly boosting international supplies, while working long-term towards the construction of a new Actinium Production Facility (APF) in Canada. The joint venture’s mission is to fulfil the unmet global manufacturing and production needs of this coveted radioisotope with significant potential in the fight against cancer.

For further information, please contact:

Ariceum Therapeutics
Manfred Rüdiger, CEO
Email: info@ariceum-therapeutics.com

Optimum Strategic Communications
Zoe Bolt, Charlotte Hepburne-Scott, Elena Bates
Tel: +44 (0) 20 3882 9621
Email: ariceum@optimumcomms.com

ITM Contact
Corporate Communications
Kathleen Noonan / Julia Westermeir
Phone: +49 89 329 8986 1500
Email: communications@itm-radiopharma.com

Investor Relations
Ben Orzelek
Phone: +49 89 329 8986 1009
Email: investors@itm-radiopharma.com

David Schilansky Appointed Chief Financial Officer of Ariceum Therapeutics

Berlin, Germany, 10 January 2025 – Ariceum Therapeutics (Ariceum), a private biotech company developing radiopharmaceutical products for the diagnosis and treatment of certain hard-to-treat cancers, today announced the appointment of David Schilansky as Chief Financial Officer with immediate effect, taking over from Rainer Sturm, who will ensure a smooth transition. David has more than 25 years of professional experience, mainly in the pharma and biotech industry, with a strong track-record in company scale-up and fundraising, including on Nasdaq.

Manfred Rüdiger, PhD, Chief Executive Officer of Ariceum Therapeutics, said: “I am delighted to welcome such a high caliber CFO to Ariceum, with a proven track record in accelerated value creation. David’s leadership and fundraising experience will be invaluable for increasing our visibility vis-à-vis the US investment community. I want to thank Rainer for his expertise, enthusiasm, energy, and for handing over a strong financial function, ready for further scale-up and internationalization.”

David Schilansky, newly appointed Chief Financial Officer of Ariceum Therapeutics, commented: “I believe Ariceum is one of the most promising biotechs in Europe, gathering fantastic technology, the right positioning, a strong management team with a stellar group of shareholders. A breakthrough company in the radiopharma space, Ariceum’s pipeline of novel candidates has the potential to transform the care of patients with aggressive cancers. These are crucial times for Ariceum and I look forward to teaming-up with the Company’s leadership to advance these important product candidates.”

Ariceum Therapeutics’ leadership team will be in San Francisco for J.P. Morgan’s 43rd Annual Healthcare Conference from January 13-16, 2025. To arrange a meeting, please contact info@ariceum-therapeutics.com.

David Schilansky’s biography

In January 2020, David Schilansky co-founded Home Biosciences, a first-in-class biotech venture builder in Continental Europe backed by Redmile Group and Sofinnova Partners, successfully building three start-ups. From 2011 to 2020, he co-headed DBV Technologies, as CFO up to 2015 then as deputy-CEO, transforming the company from a French research start-up to an international biopharma, leading two IPOs on Euronext and Nasdaq with more than one billion US dollars raised in total. David worked at Ipsen from 2005 to 2011, where he held various roles in finance, including that of Group Chief Financial Officer, before moving to DBVT. David began his career in 1999 as an investment banker in M&A at Warburg Dillon Read. He graduated with Master’s degrees from Université Paris Dauphine-PSL and Imperial College (London).

Recent developments at Ariceum

Ariceum is currently undergoing Phase 1b clinical trials for its proprietary lead radiopharmaceutical candidate, satoreotide. The Company recently published outstanding preclinical data demonstrating the use of Ac-225 satoreotide in multiple indications expressing somatostatin receptor 2, including small cell lung cancer (SCLC), pancreatic cancers, and Merkel Cell Carcinoma. Ariceum also started its Phase 1 clinical trial of ATT001 in patients with recurrent glioblastoma, positioning it as the first company to sponsor a clinical trial of Auger therapy for this aggressive form of brain cancer with no satisfactory treatment option. In addition, Ariceum has also scaled-up its global supply agreements for the medical radionuclides Actinium-225 (Ac-225) and Lutetium-177 (Lu-177) which will be used to radiolabel satoreotide and accelerate the development of Ariceum’s novel targeted radiopharmaceutical pipeline programs.

Notes to Editors

About Ariceum Therapeutics

Ariceum Therapeutics is a private, clinical stage radiopharmaceutical company focused on the diagnosis and precision treatment of certain neuroendocrine and other aggressive, hard-to-treat cancers. The name Ariceum is an anagram of ‘Marie Curie’ whose discovery of radium and polonium have been huge contributions to finding treatments for cancer.

Ariceum’s lead targeted systemic radiopharmaceutical candidate, 177Lu-satoreotide tetraxetan (“satoreotide”), is an antagonist of the somatostatin type 2 (SSTR2) receptor which is overexpressed in aggressive neuroendocrine tumours (NETs) such as small cell lung cancer (SCLC) or Merkel Cell Carcinoma (MCC), all of which have limited treatment options and poor prognosis. Satoreotide is being developed as a ‘theranostic pair’ for the combined diagnosis and targeted radionuclide treatment of these tumours. Ariceum is also developing a radiolabelled PARP-inhibitor (ATT001), currently in Phase 1 clinical development under the trial name CITADEL-123. ATT001 was part of the acquisition of Theragnostics Ltd which was closed in June 2023.

Ariceum Therapeutics, launched in 2021, acquired all rights to satoreotide from Ipsen, which has remained a shareholder of the Company. Ariceum is headquartered in Berlin, with operations in Germany, Switzerland, Australia, the United Kingdom, and the United States.

Ariceum is led by a highly experienced management team and supported by specialist investors including EQT Life Sciences (formerly LSP), HealthCap, Pureos Bioventures, Andera Partners, and Earlybird Venture Capital. For further information, please visit www.ariceum-therapeutics.com.

For further information, please contact:

Ariceum Therapeutics
Manfred Rüdiger, CEO
Email: info@ariceum-therapeutics.com

Optimum Strategic Communications
Zoe Bolt, Charlotte Hepburne-Scott, Elena Bates
Tel: +44 (0) 20 3882 9621
Email: ariceum@optimumcomms.com

Ariceum Therapeutics and NorthStar Medical Radioisotopes Announce Supply Agreement for Therapeutic Radioisotope Actinium-225

  • NorthStar will supply non-carrier added Actinium-225, a radionuclide, for use with Ariceum’s first-in-class radiopharmaceutical drug, satoreotide

Berlin, Germany, and Beloit, Wisconsin, 11 December 2024 – Ariceum Therapeutics, a private biotech company developing radiopharmaceutical products for the diagnosis and treatment of certain hard-to-treat cancers, and NorthStar Medical Radioisotopes, LLC, a global innovator in the development, production and commercialization of radiopharmaceuticals used for therapeutic applications and medical imaging, today announced the signing of a supply agreement for the therapeutic medical radioisotope, Actinium-225 (Ac-225).

Under the terms of the agreement, NorthStar will provide Ariceum with non-carrier-added (n.c.a.), high purity, Ac-225, a rare and critical isotope that is in high demand, providing Ariceum with an additional clinical source of supply for its evolving pipeline development programs. Ariceum will use NorthStar’s Ac-225 to radiolabel its proprietary peptide (SS0110) satoreotide, a first-in-class antagonist of the somatostatin receptor 2 (SSTR2). Satoreotide is being developed as a ‘theranostic pair’ for the combined diagnosis and targeted radionuclide treatment of multiple indications expressing SSTR2, such as small cell lung cancer (SCLC), pancreatic cancers, Merkel Cell Carcinoma, and other aggressive cancers.

Manfred Rüdiger, Chief Executive Officer of Ariceum Therapeutics, commented: “Satoreotide is the first Ac-225 labelled antagonist of the SSTR2 receptor targeting SCLC. The compound is scheduled to enter clinical development in the US as part of a transatlantic trial soon. The compound has demonstrated its potential as a Lutetium-177-labelled version in our ongoing Phase 1b clinical study in end stage-SCLC. Based on NorthStar’s industry leadership and commercial expertise in cutting-edge, accelerator-based radioisotope production technology, we believe that they are a reliable partner to meet Ariceum’s specific needs. In partnership with NorthStar, we look forward to progressing our clinical studies with Ac-225 and accelerating our future commercialization opportunities as we seek to deliver targeted theranostic treatments for patients.”

“Ariceum’s impressive development portfolio is focused on very aggressive, difficult-to-treat cancers and its early trial results are very exciting,” said Frank Scholz, President and Chief Executive Officer of NorthStar. “At NorthStar, our goal is to reduce or eliminate concerns about adequate availability of Ac-225 for clinical trials and patient medicines, which have held back exploration of powerful new pathways to attack these diseases for the millions of patients who today have limited treatment options available. We are proud to use our expertise and capabilities to provide innovative companies like Ariceum with high purity, n.c.a. Ac-225, that will help make potential new treatment therapies a prospect for the benefit of patients.”

-Ends-

CONTACTS:

For Ariceum Therapeutics
Manfred Rüdiger, CEO
info@ariceum-therapeutics.com

Optimum Strategic Communications
Zoe Bolt, Charlotte Hepburne-Scott, Elena Bates
Tel: +44 (0) 20 3882 9621
ariceum@optimumcomms.com

For NorthStar Medical Radioisotopes, LLC
Corporate:
Alison Hess
Vice President Chief of Staff
Tel : +1 608-295-9806
ahess@northstarnm.com

Investor Relations:
Paul Estrem
Executive Vice President and Chief Financial Officer
Tel: + 1 608-987-8318

About Ariceum Therapeutics, GmbH
Ariceum Therapeutics (Ariceum) is a private, clinical stage radiopharmaceutical company focused on the diagnosis and precision treatment of certain neuroendocrine and other aggressive, hard-to-treat cancers. The name Ariceum is an anagram of ‘Marie Curie’ whose discovery of radium and polonium have been huge contributions to finding treatments for cancer.

Ariceum’s lead targeted systemic radiopharmaceutical product, 177Lu-satoreotide tetraxetan (“satoreotide”), is an antagonist of the somatostatin type 2 (SSTR2) receptor which is overexpressed in neuroendocrine tumours (NETs) and some aggressive cancers such as small cell lung cancer (SCLC), or Merkel Cell Carcinoma (MCC), all of which have few treatment options and poor prognosis. Satoreotide is being developed as a ‘theranostic pair’ for the combined diagnosis and targeted radionuclide treatment of these tumours. Ariceum is also developing a radiolabelled PARP-inhibitor (ATT001), currently in Phase 1 clinical development under the trial name CITADEL-123. ATT001 was part of the acquisition of Theragnostics Ltd which was closed in June 2023.

Ariceum Therapeutics, launched in 2021, acquired all rights to satoreotide from Ipsen. Ipsen remains a shareholder in the Company. Ariceum is headquartered in Berlin, with operations in Germany, Switzerland, Australia, United Kingdom and United States of America and with activities currently across the globe.

Ariceum is led by a highly experienced management team and supported by specialist investors including EQT Life Sciences (formerly LSP), HealthCap, Pureos Bioventures, Andera Partners and Earlybird Venture Capital. For further information, please visit www.ariceum-therapeutics.com.

About NorthStar Medical Radioisotopes, LLC (NorthStar)
NorthStar Medical Radioisotopes is a commercial-stage radiopharmaceutical company at the forefront of advancing patient care by utilizing novel technologies to produce commercial-scale radioisotopes that, once attached to a molecule, have the ability to detect and treat cancer and other serious diseases. NorthStar’s expanding industry-leading position in the emerging field of radiopharmaceutical therapy is supported by its unique capabilities in the sophisticated production of radioisotopes, proven management team, and state-of-the-art, environmentally preferable technologies. NorthStar routinely produces copper-67 (Cu-67) and is poised to be the first commercial-scale producer of non-carrier-added (n.c.a.) actinium-225 (Ac-225). The Company’s Radiopharmaceutical Contract Development and Manufacturing Organization (CDMO) services unit provides customized service offerings and specialized radiopharmaceutical expertise to help biopharmaceutical companies rapidly advance their development and commercial programs. For more information about NorthStar’s comprehensive portfolio and patient-focused services, visit: www.northstarnm.com.

Ariceum Therapeutics and Eckert & Ziegler Sign Global Supply Agreement for the Development of Next-Generation Radiotherapeutics for Precision Cancer Treatments

Berlin, Germany, December 5, 2024 – Ariceum Therapeutics (Ariceum), a private biotech company developing radiopharmaceutical products for the diagnosis and treatment of certain hard-to-treat cancers, and Eckert & Ziegler, one of the world’s largest providers of isotopes for medical, scientific and industrial use, today announced the signing of a global supply agreement for the medical radionuclides Actinium-225 (Ac-225) and Lutetium-177 (Lu-177).

Following limited global availability, alongside increasing demand for Ac-225, which comes with intricate manufacturing complexities, this collaboration is a significant step forward in accelerating Ariceum’s novel targeted radiopharmaceutical pipeline programs.

Under the terms of the agreement, Eckert & Ziegler will supply Ariceum with the required quantities of non-carrier-added (n.c.a.) Ac-225 and Lu-177. Both radionuclides will be used to radiolabel Ariceum’s proprietary lead radiopharmaceutical drug (SS0110) satoreotide targeting hard-to-treat cancers in clinical studies and subsequent commercial phases. The agreement also includes options for expansion to other drugs as well as the use of additional radionuclides in preparation for future commercialisation activities.

Manfred Rüdiger, Chief Executive Officer of Ariceum Therapeutics, said: “This important global supply agreement with Eckert & Ziegler for n.c.a. Ac-225 and Lu-177 will ensure an adequate supply of radionuclide isotopes to conduct our clinical trials. We are looking forward to working with the Eckert & Ziegler team to build a robust supply chain and to reliably deliver targeted theranostic treatments for patients with hard-to-treat cancers. Our lead radiopharmaceutical drug, satoreotide is a first-in-class, antagonist of the somatostatin receptor 2 (SSTR2) labelled with Ac-225 to enter clinical development in small cell lung cancer and in Merkel Cell Carcinoma very soon.”

Dr. Harald Hasselmann, Chief Executive Officer of Eckert & Ziegler, commented: “In collaborating with Ariceum, we support their mission to develop innovative radiopharmaceuticals for the benefit of patients. Both the production start for Ac-225, announced earlier this week, and the successful European approval of Theralugand®, show that our goal is to sustainably reduce the shortage of high-quality radioisotopes. We aim to foster the progress of novel treatments in clinical trials and beyond, and thus contribute to saving lives.”

-Ends-

CONTACTS:

For Ariceum Therapeutics
Manfred Rüdiger, CEO
info@ariceum-therapeutics.com

Optimum Strategic Communications
Zoe Bolt, Charlotte Hepburne-Scott, Elena Bates
Tel: +44 (0) 20 3882 9621
ariceum@optimumcomms.com

Eckert & Ziegler SE
Robert-Rössle-Str. 10, 13125 Berlin, Deutschland
Jan Schöpflin, Marketing / Karolin Riehle, Investor Relations
jan.schoepflin@ezag.de / karolin.riehle@ezag.de
Tel.: +49 (0) 30 / 94 10 84-138; www.ezag.com

About Ariceum Therapeutics, GmbH
Ariceum Therapeutics (Ariceum) is a private, clinical stage radiopharmaceutical company focused on the diagnosis and precision treatment of certain neuroendocrine and other aggressive, hard-to-treat cancers. The name Ariceum is an anagram of ‘Marie Curie’ whose discovery of radium and polonium have been huge contributions to finding treatments for cancer.

Ariceum’s lead targeted systemic radiopharmaceutical product, 177Lu-satoreotide tetraxetan (“satoreotide”), is an antagonist of the somatostatin type 2 (SSTR2) receptor which is overexpressed in neuroendocrine tumours (NETs) and some aggressive cancers such as small cell lung cancer (SCLC), or Merkel Cell Carcinoma (MCC), all of which have few treatment options and poor prognosis. Satoreotide is being developed as a ‘theranostic pair’ for the combined diagnosis and targeted radionuclide treatment of these tumours. Ariceum is also developing a radiolabelled PARP-inhibitor (ATT001), currently in Phase 1 clinical development under the trial name CITADEL-123. ATT001 was part of the acquisition of Theragnostics Ltd which was closed in June 2023.

Ariceum Therapeutics, launched in 2021, acquired all rights to Satoreotide from Ipsen. Ipsen remains a shareholder in the Company. Ariceum is headquartered in Berlin, with operations in Germany, Switzerland, Australia, United Kingdom and United States of America and with activities currently across the globe.

Ariceum is led by a highly experienced management team and supported by specialist investors including EQT Life Sciences (formerly LSP), HealthCap, Pureos Bioventures, Andera Partners and Earlybird Venture Capital. For further information, please visit www.ariceum-therapeutics.com.

About Eckert & Ziegler SE
Eckert & Ziegler SE, with more than 1,000 employees, is a leading specialist in isotope-related components for nuclear medicine and radiation therapy. The company offers a broad range of services and products for the radiopharmaceutical industry, from early development work to contract manufacturing and distribution. Eckert & Ziegler shares (ISIN DE0005659700) are listed in the TecDAX index of Deutsche Börse. For more information visit: www.ezag.com
Contributing to saving lives.

 

Ariceum Therapeutics Presents Outstanding Data on its First-in-Class Radiopharmaceutical Drug 225Ac-Satoreotide at the European Association of Nuclear Medicine 2024

  • 225Ac-Satoreotide is a first-in-class somatostatin receptor 2 antagonist targeting extensive stage small cell lung cancer and is the first antagonist labelled with 225Ac to enter clinical development
  • Satoreotide expressed a superior pharmacokinetic profile relative to DOTA-TATE with a higher pre-clinical anti-tumour efficacy, irrespective of radionuclide used
  • 100% survival with a single dose of 30 kBq 225Ac-satoreotide but not with 225Ac-DOTA-TATE

Berlin, Germany, 22 October 2024 – Ariceum Therapeutics (Ariceum), a private biotech company developing radiopharmaceutical products for the diagnosis and treatment of certain hard-to-treat cancers, today announces that it presented data on its proprietary radiolabelled peptide SS0110 (satoreotide), a first-in-class antagonist of the somatostatin receptor 2 (SSTR2), at this year’s European Association of Nuclear Medicine (EANM) Annual Conference, held in Hamburg, Germany from 19-23 October 2024.

The Top-Rated Oral Presentation (TROP) entitled ‘225Ac-SSO110 induces long-lasting anti-tumour responses in contrast to 225Ac-DOTA-TATE and 161Tb-DOTA-TATE in the treatment of SSTR2-positive tumour xenografts’, details the anti-tumour efficacy of different radiolabelled satoreotide antagonists (225Ac, 161Tb, 177Lu-labelled SSO110) versus respective DOTA-TATE agonists (225Ac- and 161Tb-labelled DOTA-TATE) in mice engrafted with SSTR2 positive xenografts of small cell lung cancer (SCLC) and pancreatic cancer using clinically relevant associated dose ranges.

Results demonstrate that 225Ac-satoreotide shows the strongest anti-tumoural effect in vivo at a low single dose when evaluating satoreotide and DOTA-TATE radiolabelled with different radionuclides. Irrespective of the radionuclides used, satoreotide demonstrated a higher pre-clinical anti-tumour efficacy when compared to DOTA-TATE which was less potent and required increased dose levels. Satoreotide was well tolerated across all dose levels and with all used radionuclides. These comparisons between satoreotide and DOTA-TATE will facilitate and guide further clinical development of satoreotide across multiple indications expressing SSTR2, such as SCLC, pancreatic cancers and Merkel Cell Carcinoma (MCC).

Previous comparisons between satoreotide and DOTA-TATE demonstrated that antagonist, 225Ac-satoreotide, is multiple times more potent than SSTR2 agonist, 225Ac-DOTA-TATE, signifying a durable complete response in standard murine xenograft models of SCLC in animal models, versus tumour growth delay.

Ariceum had previously shown at the Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting 2024 that 212Pb was not seen to be more potent than Lutetium or Terbium but caused more side effects and hence was not further pursued.

Manfred Rüdiger, Chief Executive Officer at Ariceum Therapeutics, said: “These results provide strong evidence for satoreotide and its potential to clinically outperform SSTR2 targeting agonists, by demonstrating significantly better efficacy in tumour growth control, up to complete tumour eradication depending on isotope used. In addition, when a single dose of 30 kBq 225Ac-satoreotide was administered, we observed high frequency of complete durable responses and 100% survival which strongly supports further clinical development for the treatment of SCLC, MCC and other cancers.”

Details of the oral presentation are as follow:

Title: 225Ac-SSO110 induces long-lasting anti-tumour responses in contrast to 225Ac-DOTA-TATE and 161Tb-DOTA-TATE in the treatment of SSTR2-positive tumour xenografts

Presenting Author: Prachi Desai, Scientist at Ariceum Therapeutics

Session Number: 1204

Session Title: M2M Track – TROP Session: Radiopharmaceutical Sciences + Translational Molecular Imaging & Therapy Committee: From Radionuclide to Clinical Translation

Oral Presentation Date & Time: Tuesday 22 October 2024, 09:00 AM – 09:10 AM CEST

Abstract Authors: Prachi Desai, Manuel Sturzbecher-Hoehne, Dennis Mewis, Manfred Ruediger & Anika Jaekel of Ariceum Therapeutics

Session Date & Time: Tuesday 22 October 2024, 08:00 AM – 09:30 AM CEST

Location: Session Hall X1-X4

Abstracts are available in the September edition of Springer’s European Journal of Nuclear Medicine and Molecular Imaging (EJNMMI) abstract book here and on the Ariceum website here.

-Ends-

For further information, please contact:

Ariceum Therapeutics
Manfred Rüdiger, CEO
Email: info@ariceum-therapeutics.com

Optimum Strategic Communications
Zoe Bolt, Charlotte Hepburne-Scott, Elena Bates
Tel: +44 (0) 20 3882 9621
Email: ariceum@optimumcomms.com

 

Notes to Editors

About Ariceum Therapeutics

Ariceum Therapeutics (Ariceum) is a private, clinical stage radiopharmaceutical company focused on the diagnosis and precision treatment of certain neuroendocrine and other aggressive, hard-to-treat cancers. The name Ariceum is an anagram of ‘Marie Curie’ whose discovery of radium and polonium have been huge contributions to finding treatments for cancer.

Ariceum’s lead targeted systemic radiopharmaceutical product, 177Lu-satoreotide tetraxetan (“Satoreotide”), is an antagonist of the somatostatin type 2 (SSTR2) receptor which is overexpressed in neuroendocrine tumours (NETs) and some aggressive cancers such as small cell lung cancer (SCLC), or Merkel Cell Carcinoma (MCC), all of which have few treatment options and poor prognosis. Satoreotide is being developed as a ‘theranostic’ pair for the combined diagnosis and targeted radionuclide treatment of these tumours. Ariceum is also developing a radiolabelled PARP-inhibitor (ATT001), currently in Phase 1 clinical development under the trial name CITADEL-123. ATT001 was part of the acquisition of Theragnostics Ltd which was closed in June 2023.

Ariceum Therapeutics, launched in 2021, acquired all rights to Satoreotide from Ipsen. Ipsen remains a shareholder in the Company. Ariceum is headquartered in Berlin, with operations in Germany, Switzerland, Australia, United Kingdom and United States of America and with activities currently across the globe.

Ariceum is led by a highly experienced management team and supported by specialist investors including EQT Life Sciences (formerly LSP), HealthCap, Pureos Bioventures, Andera Partners and Earlybird Venture Capital. For further information, please visit  www.ariceum-therapeutics.com.

About European Association of Nuclear Medicine (EANM)
The European Association of Nuclear Medicine (EANM) is a non-profit organization that promotes nuclear medicine and aims to improve public health. The EANM’s mission is to advance nuclear medicine through personalized healthcare, innovation in diagnosis and treatment, and raising awareness of nuclear medicine.